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Thorne Methyl-Guard Plus Active Folate 5-MTHF – 90 Capsules
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Thorne Methyl-Guard Plus Active Folate 5-MTHF – 90 Capsules
  • Thorne Methyl-Guard Plus Active Folate 5-MTHF – 90 Capsules
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Thorne Methyl-Guard Plus Active Folate 5-MTHF – 90 Capsules

Thorne Methyl-Guard Plus Active Folate 5-MTHF – 90 Capsules

$58.00 $62.00

22 reviews

All Skin Types, Including Sensitive.

Thorne Methyl-Guard Plus is an active B-vitamin formula built around 5-MTHF (the bioactive form of folate) alongside methylated B2, B6, and B12, plus betaine (trimethylglycine). It's designed to deliver methyl donors the body can use directly, without relying on the conversion steps that standard folic acid and cyanocobalamin require. The bottle contains 90 capsules.
Key Ingredients
  • L-5-MTHF (Active Folate): the already-active form of folate, which bypasses the enzymatic conversion some people process less efficiently.
  • Riboflavin 5'-Phosphate (B2) and Pyridoxal 5'-Phosphate (B6): bioactive, tissue-ready forms of these methylation-supporting B vitamins.
  • Methylcobalamin (B12): the active, methylated form of vitamin B12.
  • Betaine Anhydrous (TMG): an additional methyl donor that supports the broader methylation cycle.
Key Benefits
  • Formulated to support healthy methylation*
  • May help support already-healthy homocysteine levels*
  • Gluten-free, dairy-free, and soy-free capsule formula
How To Use

Adults looking for targeted methylation and active B-vitamin support, including those who prefer methylated folate and B12 over standard folic acid and cyanocobalamin forms. This statement has not been evaluated by the FDA and this product is not intended to diagnose, treat, cure, or prevent any disease.
  • 5 stars: 19 (86%)
  • 4 stars: 3 (14%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
V
Valerie R.
Simple instructions and tidy packaging

The serving instructions are clear and the capsules are a convenient format. The package arrived looking clean and properly sealed. It is easy to understand how to use it as directed.

P
Philip H.
A simple wellness-routine addition

Packaging feels tidy and the label is easy to read. The capsules are straightforward to take as part of my normal daily routine. Everything feels straightforward and well organized.

C
Chelsea B.
Neat packaging and clear directions

I like products that do not make the routine complicated, and this format is very straightforward. The bottle and label also look neat. Everything feels straightforward and well organized.

J
Jackie T.
Convenient product for everyday use

A simple addition to an everyday routine. I especially liked the tidy packaging and clear directions. Overall, the product presentation made a good impression.

K
Katie V.
Simple, practical and well presented

This is easy to keep on my shelf and work into a regular routine. The package arrived in good condition and was simple to understand. The overall experience is simple and positive.

B
Barbara K.
Smooth ordering and neat product

The capsule format is practical and uncomplicated. I also liked the clear label and overall presentation. Overall, the product presentation made a good impression.

D
David L.
Good quality presentation

Everything was sealed and presented neatly. The instructions are straightforward, which makes the product easy to fit into my routine. It is easy to understand how to use it as directed.

J
John s.
Clear label and convenient capsules

I appreciate the simple serving format and clean presentation. It is convenient to keep with my other everyday wellness products. I like the clean, uncomplicated presentation.

A
Ari D.
Nicely sealed and presented

The product is easy to store, easy to read, and simple to use as directed. Overall, the presentation feels organized and convenient. I like the clean, uncomplicated presentation.

R
Randee M.
Well packed and easy to use

The bottle arrived neatly packed and the directions are easy to follow. I like how simple the capsule format is to keep in a regular routine. The overall experience is simple and positive.

M
Michael G.
Pleasant overall experience

A simple addition to an everyday routine. I especially liked the tidy packaging and clear directions. Overall, the product presentation made a good impression.

C
Cesar A.
Easy daily-use format

The serving instructions are clear and the capsules are a convenient format. The package arrived looking clean and properly sealed. It is easy to understand how to use it as directed.

A
Alex B.
Very convenient format

The product is easy to store, easy to read, and simple to use as directed. Overall, the presentation feels organized and convenient. I like the clean, uncomplicated presentation.

T
Tarshi H.
Good addition to my routine

The capsule format is practical and uncomplicated. I also liked the clear label and overall presentation. Overall, the product presentation made a good impression.

A
Anhnam N.
Convenient everyday option

I appreciate the simple serving format and clean presentation. It is convenient to keep with my other everyday wellness products. I like the clean, uncomplicated presentation.

S
Stella S.
Simple and effective for Thorne Methyl-Guard Plus Act

The delivery was quick and the packaging looked professional. I appreciate the fast delivery and neat presentation.

Y
Yvonne P.
Easy to keep consistent with

I like products that do not make the routine complicated, and this format is very straightforward. The bottle and label also look neat. Everything feels straightforward and well organized.

H
Henry p.
Straightforward and nicely packaged

Everything was sealed and presented neatly. The instructions are straightforward, which makes the product easy to fit into my routine. It is easy to understand how to use it as directed.

G
Gale C.
Clean presentation and simple routine

Packaging feels tidy and the label is easy to read. The capsules are straightforward to take as part of my normal daily routine. Everything feels straightforward and well organized.

J
Jill S.
Practical capsule format

This is easy to keep on my shelf and work into a regular routine. The package arrived in good condition and was simple to understand. The overall experience is simple and positive.

E
Elizabeth K.
Feels premium

No issues at all with this order. It was exactly what I needed for my routine.

V
Virginia A.
Easy to add to a daily routine

The bottle arrived neatly packed and the directions are easy to follow. I like how simple the capsule format is to keep in a regular routine. The overall experience is simple and positive.

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Frequently Asked Questions

  • Most of our products are formulated to be gentle. However, we always recommend a patch test before full application, especially for sensitive skin.
  • Results vary depending on skin type and consistency of use. Many users notice improvements within 2–4 weeks of regular application.
  • Yes, unless otherwise stated. Follow the recommended usage instructions on the product page for best results.
  • Yes. This product is designed to work within a skincare routine. If using active ingredients, introduce gradually and monitor skin response.
  • If you are pregnant or breastfeeding, consult your healthcare professional before introducing new skincare products.
  • Most of our formulations are non-comedogenic. Individual reactions vary, so discontinue use if irritation occurs.
  • Yes. Apply in the recommended order within your routine. Allow the product to absorb fully before layering.
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